期刊名称：Walailak Journal of Science and Technology (WJST)
印刷版ISSN：2228-835X
出版年度：2016
卷号：13
期号：10
页码：875-892
DOI：10.14456/vol13iss7pp%p
出版社：Institute of Research and Development, Walailak University.
其他摘要：CoQ 10 -enriched shells of ultra-small nanostructured lipid carriers (usNLC), or oil with dissolved CoQ 10 surrounding a based core of a solid lipid and oil mixture, were successfully produced using a hot high pressure homogenization technique. Then, 2 different concentrations of CoQ 10 were loaded into usNLC, to compare the effect of particle size on antioxidant capacity. A particle size of 5.0 % CoQ 10 -loaded usNLC (about 80 nm) was approximately 2 times larger than 0.5 % CoQ 10 -loaded usNLC (about 50 nm), and the lightness of the yellow-colored pigment of CoQ 10 was observable by the naked eye as regards the decrease in particle size. In addition, the spherical shape of the empty usNLC and CoQ 10 -enriched shell of usNLC was shown by a transmission electron microscopy (TEM). Interestingly, a 10 times lower CoQ 10 loading capacity into usNLC with a smaller size showed a higher antioxidant capacity than a higher CoQ 10 loading and a bulk solution of CoQ 10 , by decreasing DPPH free radical scavenging activity using the DPPH method and increasing the resistance of red blood cells to oxidative damage using a biological Kit Radicaux Libres (KRL) test. Therefore, this study suggests that the smaller particle size of CoQ 10 -enriched shells of usNLC deserves to be developed and evaluated further in vivo study, in order to prove the antioxidant effects.
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