The article presents models analysis which exist in entrepreneurial activity; distinguishes the stages and peculiarities of entrepreneurial forming and development, reveals the essence of innovative entrepreneurship in conditions of education, science and manufacture integration, finds regularities and proves the principles of teachers innovative and entrepreneurial competence forming in higher technical schools, and also discloses regional practice of innovative and entrepreneurial activities implementation in the educational institutions of professional education. The material of this article is of practical value for the administration and the teaching staff of higher educational institutions of professional education in innovative and entrepreneurial activities implementation in the University, and also for teachers and students innovative and entrepreneurial competence forming.