摘要：Introduction: Evaluation of the susceptibility of isolated fungi as well as the type and activity of enzymes they release allows determining their pathogenicity.Purpose: To assess potential correlations between drug susceptibility and enzymatic activity of strains isolated from mobile phone and hand surfacesMaterials and methods: The mycological evaluation included 175 mobile phones and 175 hands of the phone owners. Drug susceptibility was assessed using the FUNGITEST; enzymatic activity was evaluated using the API ZYM test.Results: We found significant correlations between increased resistance to 5-fluorocytosine, ketoconazole, fluconazole and higher activity of six selected enzymes for Candida glabrata strains isolated from hand surfaces. We also found significant correlations between increased resistance to 5-fluorocytosine, ketoconazole, miconazole, itraconazole and higher activity of six selected enzymes for Candida albicans strains isolated from hand surfaces. We found significant correlations between increased resistance to 5-fluorocytosine, ketoconazole, itraconazole, fluconazole and higher activity of six selected enzymes for Candida krusei strains isolated from hand surfaces as well as an increased resistance to 5-fluorocytosine, ketoconazole, itraconazole, fluconazole and higher activity of five selected enzymes for strains isolated from phone surfaces.Conclusions: We found varying correlations between enzymatic activity and drug resistance depending on the site of isolation and the species/genus of fungi. The drugs to which the evaluated strains showed resistance were the same for hand and mobile phone isolates.
关键词：Candida; Fungitest; API ZYM; hands; mobile telephones
