摘要：The replacement of nucleosomal H2A with the histone variant H2A.Z is critical for regulating DNAmediatedprocesses across eukaryotes and for early development of multicellular organisms. Howthis variant performs these seemingly diverse roles has remained largely enigmatic. Here, we discussrecent mechanistic insights that have begun to reveal how H2A.Z functions as a molecular rheostatfor gene control. We focus on specific examples in metazoans as a model for understanding howH2A.Z integrates information from histone post-translational modifications, other histone variants,and transcription factors (TFs) to regulate proper induction of gene expression programs in responseto cellular cues. Finally, we propose a general model of how H2A.Z incorporation regulates chromatinstates in diverse processes.
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