摘要：Acute myocardial infarction (AMI) and sudden cardiac death (SCD) are among the most serious andcatastrophic of acute cardiac disorders, accounting for hundreds of thousands of deaths each yearworldwide. Although the incidence of AMI has been decreasing in the US according to the American HeartAssociation, heart disease is still the leading cause of mortality in adults. In most cases of AMI and in amajority of cases of SCD, the underlying pathology is acute intraluminal coronary thrombus formationwithin an epicardial coronary artery leading to total or near-total acute coronary occlusion. This articlesummarizes our current understanding of the pathophysiology of these acute coronary syndromes andbriefly discusses new approaches currently being researched in an attempt to define and ultimately reducetheir incidence.
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