摘要：Inflammation is a double-edged sword. While short-lived, acute inflammation is essential for the repairand resolution of infection and damage, uncontrolled and unresolved chronic inflammation is central toseveral diseases, including cancer, autoimmune diseases, allergy, metabolic disease, and cardiovasculardisease. This report aims to review the literature regarding several members of the nucleotide-bindingdomain, leucine-rich repeat-containing receptor (NLR) family of pattern recognition sensors/receptorsthat serve as checkpoints for inflammation. Understanding the negative regulation of inflammation ishighly relevant to the development of therapeutics for inflammatory as well as infectious diseases.
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