摘要：As mitochondria are the powerhouses of the cell, their damage during the cell suicide process ofapoptosis is essentially responsible for cellular demise in most cells. A key family of proteins, theB-cell lymphoma-2 (BCL-2) family, determines the integrity of mitochondria in the face of apoptoticinsult. A comprehensive understanding of the molecular details of how apoptosis is initiated and howit culminates is essential if apoptosis is to fulfil its undoubted potential as a therapeutic target to treatdiseases ranging from cancer to neurodegenerative conditions. Recent advances have providedsignificant insight into the control of this fundamental process while prompting a re-evaluation ofwhat was considered dogma in the field. Emerging evidence also points to a potential overarchingcontrol network that governs not only apoptosis but other fundamental mitochondrial processes,including mitochondrial fission/fusion and quality control.
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