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  • 标题:Asymmetric Conjugate Additions of Carbonyl Compounds to Nitroalkenes under Solvent-Free Conditions Using Fluorous Diaminomethylenemalononitrile Organocatalyst
  • 本地全文:下载
  • 作者:Shin-ichi Hirashima ; Takafumi Narushima ; Masahiro Kawada
  • 期刊名称:Chemical and Pharmaceutical Bulletin
  • 印刷版ISSN:0009-2363
  • 电子版ISSN:1347-5223
  • 出版年度:2017
  • 卷号:65
  • 期号:12
  • 页码:1185-1190
  • DOI:10.1248/cpb.c17-00596
  • 语种:English
  • 出版社:The Pharmaceutical Society of Japan
  • 摘要:

    The novel fluorous organocatalyst bearing a diaminomethylenemalononitrile motif is prepared. The fluorous organocatalyst efficiently promotes asymmetric conjugate additions of ketones to nitroalkenes and results in high yields of these addition products with excellent enantioselectivities under solvent-free conditions.

  • 关键词:organocatalyst;fluorous;conjugate addition;solvent-free
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