首页    期刊浏览 2025年05月24日 星期六
登录注册

文章基本信息

  • 标题:An Efficient Method for the Synthesis of 2′,3′-Nonsubstituted Cycloalkane-1,3-dione-2-spirocyclopropanes Using (2-Bromoethyl)diphenylsulfonium Trifluoromethanesulfonate
  • 本地全文:下载
  • 作者:Hisanori Nambu ; Naoki Ono ; Wataru Hirota
  • 期刊名称:Chemical and Pharmaceutical Bulletin
  • 印刷版ISSN:0009-2363
  • 电子版ISSN:1347-5223
  • 出版年度:2016
  • 卷号:64
  • 期号:12
  • 页码:1763-1768
  • DOI:10.1248/cpb.c16-00625
  • 语种:English
  • 出版社:The Pharmaceutical Society of Japan
  • 摘要:

    An efficient and practical synthesis of 2′,3′-nonsubstituted cyclohexane-1,3-dione-2-spirocyclopropanes using a sulfonium salt was achieved. The reaction of 1,3-cyclohexanediones and (2-bromoethyl)diphenylsulfonium trifluoromethanesulfonate with powdered K2CO3 in EtOAc at room temperature (r.t.) provided the corresponding spirocyclopropanes in high yields. The synthetic method was also applied to 1,3-cyclopentanedione, 1,3-cycloheptanedione, 1,3-indanedione, acyclic 1,3-diones, ethyl acetoacetate, and Meldrum’s acid.

  • 关键词:cyclopropane;sulfonium salt;spiro compound;1,3-cyclohexanedione;double alkylation
国家哲学社会科学文献中心版权所有