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  • 标题:Asymmetric Chlorination of β-Keto Esters Using Diaminomethylenemalononitrile Organocatalyst
  • 本地全文:下载
  • 作者:Takaaki Sakai ; Shin-ichi Hirashima ; Kosuke Nakashima
  • 期刊名称:Chemical and Pharmaceutical Bulletin
  • 印刷版ISSN:0009-2363
  • 电子版ISSN:1347-5223
  • 出版年度:2016
  • 卷号:64
  • 期号:12
  • 页码:1781-1784
  • DOI:10.1248/cpb.c16-00722
  • 语种:English
  • 出版社:The Pharmaceutical Society of Japan
  • 摘要:

    Diaminomethylenemalononitrile organocatalysts promote the asymmetric chlorination of simple cyclic β-keto esters such as methyl, ethyl, and benzyl esters of 1-oxo-2,3-dihydro-1 H -indene-2-carboxylic acid. This affords the corresponding chiral α-chlorinated carbonyl products in excellent yields with high enantioselectivities.

  • 关键词:organocatalyst;asymmetric chlorination;β-keto ester
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