摘要:Objective: Journal impact factor (JIF) is often used as a measure of journal quality. A retrospective cohort study determined the ability of clinical article and journal characteristics, including appraisal measures collected at the time of publication, to predict subsequent JIFs. Methods: Clinical research articles that passed methods quality criteria were included. Each article was rated for relevance and newsworthiness by 3 to 24 physicians from a panel of more than 4,000 practicing clinicians. The 1,267 articles (from 103 journals) were divided 60∶40 into derivation (760 articles) and validation sets (507 articles), representing 99 and 88 journals, respectively. A multiple regression model was produced determining the association of 10 journal and article measures with the 2007 JIF. Results: Four of the 10 measures were significant in the regression model: number of authors, number of databases indexing the journal, proportion of articles passing methods criteria, and mean clinical newsworthiness scores. With the number of disciplines rating the article, the 5 variables accounted for 61% of the variation in JIF (R2 = 0.607, 95% CI 0.444 to 0.706, P <0.001). Conclusion: For the clinical literature, measures of scientific quality and clinical newsworthiness available at the time of publication can predict JIFs with 60% accuracy. Highlights Journal impact factors (JIFs) can be predicted with 60% accuracy soon after publication of articles. Quality indicators and clinician ratings of newsworthiness of individual newly published clinical studies predicted JIF. Implications JIFs can guide practicing clinicians to methodologically sound studies and articles with new information of importance to caring for their patients (newsworthiness). Editors of clinical journals may be able to improve the impact of their publications by assessing study methods carefully, using more referees to assess the clinical interest in submitted articles, and nominating their journals for indexing in databases. For new journals, measures of article quality and clinical interest may predict future JIF.