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  • 标题:Prenatal exposures and exposomics of asthma
  • 本地全文:下载
  • 作者:Hyunok Choi ; Mark T. McAuley ; David A. Lawrence
  • 期刊名称:AIMS Environmental Science
  • 印刷版ISSN:2372-0344
  • 电子版ISSN:2372-0352
  • 出版年度:2015
  • 卷号:2
  • 期号:1
  • 页码:87-109
  • DOI:10.3934/environsci.2015.1.87
  • 摘要:This review examines the causal investigation of preclinical development of childhood asthma using exposomic tools. We examine the current state of knowledge regarding early-life exposure to non-biogenic indoor air pollution and the developmental modulation of the immune system. We examine how metabolomics technologies could aid not only in the biomarker identification of a particular asthma phenotype, but also the mechanisms underlying the immunopathologic process. Within such a framework, we propose alternate components of exposomic investigation of asthma in which, the exposome represents a reiterative investigative process of targeted biomarker identification, validation through computational systems biology and physical sampling of environmental media.
  • 关键词:air pollution; prenatal; early; life; in utero; exposome; asthma; immune; metabolomics; indoor
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