首页    期刊浏览 2024年11月24日 星期日
登录注册

文章基本信息

  • 标题:Stabilizers of edaravone aqueous solution and their action mechanisms. 2. Glutathione
  • 本地全文:下载
  • 作者:Masahiko Tanaka ; Satsuki Motomiya ; Akio Fujisawa
  • 期刊名称:Journal of Clinical Biochemistry and Nutrition
  • 印刷版ISSN:0912-0009
  • 电子版ISSN:1880-5086
  • 出版年度:2017
  • 卷号:61
  • 期号:3
  • 页码:164-168
  • DOI:10.3164/jcbn.17-75
  • 语种:English
  • 出版社:The Society for Free Radical Research Japan
  • 摘要:Edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one) has garnered attention since its approval for amyotrophic lateral sclerosis in Japan (2015) and the United States (2017). Edaravone is administered intravenously, and as such, is distributed in the form of an aqueous solution. However, aqueous solutions of edaravone are very unstable because they present as edaravone anions, which become edaravone radicals when the anion donates an electron to free radicals including oxygen. In this study, glutathione (GSH) stabilized an aqueous edaravone solution during storage at 60°C for 4 weeks, and prevented the formation of potentially carcinogenic phenylhydrazine, while cysteine did not. One possible explanation is that GSH undergoes intermolecular hydrogen bonding with edaravone anions, while cysteine does not, as it favors intramolecular hydrogen boding. The combination of GSH and sodium bisulfite (NaHSO3) stabilized aqueous edaravone at room temperature for more than 1 year even under aerobic conditions. However, the U.S. Food and Drug Administration cautioned that NaHSO3 may cause allergic reactions. Therefore, we developed a stable edaravone aqueous solution without using NaHSO3, namely a combination of GSH with deoxygenation, which resulted in better stabilization of aqueous edaravone than the combination of GSH and NaHSO3.
  • 关键词:edaravone;sodium bisulfite;cysteine;glutathione;deoxygenation
国家哲学社会科学文献中心版权所有