期刊名称：Brain. Broad Research in Artificial Intelligence and Neuroscience
印刷版ISSN：2067-3957
出版年度：2017
卷号：8
期号：4
页码：91-98
语种：English
出版社：EduSoft publishing
摘要：Current work reviews the concept, pathological mechanism and the process of diagnosing diffuse axonal lesions (DAI). The pathological mechanism underlying DAI is complicated, including axotomy with the appearance of retraction bulbs, interrupted protein transport along axonal neurophilaments, massive influx of calcium ions and calpain-mediated hydrolysis, axonal cytoskeletal cell degradation, beta-amyloid precursor protein accumulation and changes in glial cells. The transition from primary axotomy to secondary axotomy causes a very complex, calciumdependent biochemical cascade.
