Introduction: The conflict in the Syrian Arab Republic has been ongoing since 2011. Since the war broke out, many Syrians have evacuated Jordan as refugees. 28% of refugees have some kind of functional disorder. We conducted the present study to identify the health conditions of Syrian refugee with disabilities (Person With Disabilities: PWDs) in urban area of Jordan and the situations of their and their families' social participation. Methods: The subjects of the study were twelve participants of PWDs and their families in Jordan. We conducted semi-structured interview between August 2014 and December 2016. Qualitative Content Analysis Method was performed to assess the social participation of them. Results: The social participation of PWDs were categorized under five main themes: 【Lack of health care for PWDs in urban areas】, 【Insufficient health literacy of PWDs and their family members】, 【Restriction of social participation of PWDs and their family members】, 【Spreading of disuse syndrome】 and 【Care burden on family members】. Conclusion: The study identified that the social participation of PWDs and their families in urban area could be often restricted, and that insufficient health care services, health literacy, disuse syndrome, and burdens of nursing care be correlated to the level of social participation of PWDs and their families. Therefore, It is essential that health professionals including occupational therapists provide knowledge and health services concerning the prevention of disuse syndrome and support for the empowerment of PWDs.