摘要：Celecoxib es un inhibidor de Ciclooxigenasa-2 (COX- 2), antiinflamatorio no esteroideo (AINEs) que inhibe selectivamente a dicha enzima minimizando los efectos mediados por los inhibidores de COX-1 (reacciones adversas gastrointestinales). Celecoxib posee actividades antipiréticas, antiinflamatorias y analgésicas atribuidas a la inhibición de la síntesis de prostaglandinas. Recientemente se ha reportado que la actividad analgésica de celecoxib puede involucrar otros mecanismos diferentes a la inhibición de la enzima COX-2. Sin embargo, el efecto antiinflamatorio de celecoxib se está evaluando como coadyuvante en el tratamiento de distintas patologías como cáncer, depresión, esquizofrenia y Alzheimer. El efecto terapéutico de celecoxib requiere ser explorado experimentalmente para entender los mecanismos moleculares y celulares que permiten dicha actividad farmacológica.
其他摘要：Celecoxib is an inhibitor of Cyclooxygenase-2 (COX- 2), a non-steroidal anti-inflammatory drug (NSAID) that selectively inhibits the enzyme by minimizing the effects mediated by COX-1 inhibitors (gastrointestinal adverse reactions). Celecoxib has antipyretic, anti-inflammatory and analgesic activities attributed to the inhibition of prostaglandin synthesis. It has recently been reported that the analgesic activity of celecoxib may involve mechanisms other than the inhibition of the COX-2 enzyme. However, the anti-inflammatory effect of celecoxib is being evaluated as adjuvant in the treatment of different pathologies such as cancer, depression, schizophrenia and Alzheimer’s. The therapeutic effect of celecoxib requires experimental exploration to understand the molecular and cellular mechanisms that allow such pharmacological activity.
