其他摘要：OBJECTIVE:Investigate the effect of exposure to smoking during pregnancyand early childhood on changes in the body mass index (BMI) from birthto adolescence.METHODS:A population-based cohort of children (0-5 years old) fromCuiabá, Midwest Brazil, was assessed in 1999-2000 (n=2,405). Between2009 and 2011, the cohort was re-evaluated. Information about birth weightwas obtained from medical records, and exposure to smoking duringpregnancy and childhood was assessed at the first interview. Linear mixedeffects models were used to estimate the association between exposure tomaternal smoking during pregnancy and preschool age, and the body massindex of children at birth, childhood and adolescence.RESULTS:Only 11.3% of the mothers reported smoking during pregnancy,but most of them (78.2%) also smoked during early childhood. Amongmothers who smoked only during pregnancy (n=59), 97.7% had smokedonly in the first trimester. The changes in body mass index at birth andin childhood were similar for children exposed and those not exposed tomaternal smoking. However, from childhood to adolescence the rate ofchange in the body mass index was higher among those exposed only duringpregnancy than among those who were not exposed.CONCLUSIONS:Exposure to smoking only during pregnancy, especiallyin the first trimester, seems to affect changes in the body mass index untiladolescence, supporting guidelines that recommend women of childbearingage to stop smoking.
其他关键词：Pregnant Women; Smoking; adverse effects; ChildDevelopment; Body Mass Index; Cohort Studies.
