期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2018
卷号：115
期号：2
页码：361-366
DOI：10.1073/pnas.1715788115
语种：English
出版社：The National Academy of Sciences of the United States of America
摘要：The w Mel strain of Wolbachia can reduce the permissiveness of Aedes aegypti mosquitoes to disseminated arboviral infections. Here, we report that w Mel-infected Ae. aegypti (Ho Chi Minh City background), when directly blood-fed on 141 viremic dengue patients, have lower dengue virus (DENV) transmission potential and have a longer extrinsic incubation period than their wild-type counterparts. The w Mel-infected mosquitoes that are field-reared have even greater relative resistance to DENV infection when fed on patient-derived viremic blood meals. This is explained by an increased susceptibility of field-reared wild-type mosquitoes to infection than laboratory-reared counterparts. Collectively, these field- and clinically relevant findings support the continued careful field-testing of w Mel introgression for the biocontrol of Ae. aegypti -born arboviruses.
关键词：w Mel Wolbachia ; dengue virus ; Aedes aegypti mosquito ; extrinsic incubation period ; virus transmission
