摘要：Working memory (WM) deficits are often reported in patients with Bipolar Disorder (BD). However, it is not clear the nature of these WM deficits (update or serial order processes) and their association with each BD states (euthymic, mania and depressive). This review investigated the association between BD patient’s states and the functioning of WM components. For this purpose, we carried out a systematic review fulfilling a search in the databases Medline, Scopus, SciELO and Web of Science using specific terms in the abstracts of the articles that generated 212 outcomes in the restricted period from 2005 to 2016. Twenty three papers were selected, completely read and analysed using PICOS strategy. The mood episodes predicted deficits in different components of WM in BD patients (the phonological loop or visuospatial sketchpad) and were associated with different WM processes (updating and serial recall). Lower cognitive scores persist even in remission of symptoms. This result suggests that WM deficit apparently is stage-independent in BD patients. Furthermore, findings suggest that the neutral point on Hedonic Detector component of WM could be maladjusted by BD.
关键词：emotion; working memory; Bipolar Disorder; detector hedonic; mood states
