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  • 标题:Development of Triazine-Based Benzylating Reagents Possessing t-Butyl Group on the Triazine Core: Thermally Controllable Reagents for the Initiation of Reaction
  • 本地全文:下载
  • 作者:Yukiko Karuo ; Kohei Yamada ; Munetaka Kunishima
  • 期刊名称:Chemical and Pharmaceutical Bulletin
  • 印刷版ISSN:0009-2363
  • 电子版ISSN:1347-5223
  • 出版年度:2018
  • 卷号:66
  • 期号:3
  • 页码:303-308
  • DOI:10.1248/cpb.c17-00897
  • 语种:English
  • 出版社:The Pharmaceutical Society of Japan
  • 摘要:

    Benzylating reagents, 4-(4,6-di- t -butyl-1,3,5-triazin-2-yl)-4-benzylmorpholinium triflate, and related derivatives have been developed. The reagents release benzyl triflate as a benzyl cation equivalent upon heating the solution to 40°C under neutral conditions. The O -benzylation of alcohols using a stoichiometric amount of these reagents afforded corresponding benzyl ethers in good to high yields. This was due to the presence of a bulky t -butyl group on the triazine ring of these reagents that prevents the consumption of benzyl triflate via a side reaction with a morpholinotriazine derivative.

  • 关键词:benzylating reagent;triazine;thermally controllable
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