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  • 标题:Transgenic tomatoes expressing the 6F peptide and ezetimibe prevent diet-induced increases of IFN-β and cholesterol 25-hydroxylase in jejunum
  • 本地全文:下载
  • 作者:Pallavi Mukherjee ; Greg Hough ; Arnab Chattopadhyay
  • 期刊名称:JLR Papers In Press
  • 印刷版ISSN:0022-2275
  • 电子版ISSN:1539-7262
  • 出版年度:2017
  • 卷号:58
  • 期号:8
  • 页码:1636-1647
  • DOI:10.1194/jlr.M076554
  • 语种:English
  • 出版社:American Society for Biochemistry and Molecular Biology
  • 摘要:Feeding LDL receptor (LDLR)-null mice a Western diet (WD) increased the expression of IFN-β in jejunum as determined by quantitative RT-PCR (RT-qPCR), immunohistochemistry (IHC), and ELISA (all P P P = 0.0019), and ELISA ( P P P = 0.0329 to P i ) WD induces IFN-β, CH25H, and 25-OHC in jejunum; and ii ) Tg6F and ezetimibe partially ameliorate WD-induced inflammation by preventing WD-induced increases in IFN-β, CH25H, and 25-OHC.
  • 关键词:apolipoprotein A-I mimetic peptides ; atherosclerosis ; hyperlipidemia ; oxysterols
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