期刊名称：International Journal of Computer Science Issues
印刷版ISSN：1694-0784
电子版ISSN：1694-0814
出版年度：2013
卷号：10
期号：4
出版社：IJCSI Press
摘要：Optimal control theory is applied to a controlled tumor model. Seeking to minimize the infected cells and to maximize uninfected cells, we use two controls representing drug therapy and oncolytic virotherapy. The Pontryagins maximum principle is used to characterize the optimal controls. The optimal controls are obtained by solving the optimality system. The results are analyzed and interpreted numerically using MATLAB.
关键词：Optimal control; mathematical models; oncolytic virus; Pontryagins maximum principle
