期刊名称：International Journal of Computer Science Issues
印刷版ISSN：1694-0784
电子版ISSN：1694-0814
出版年度：2013
卷号：10
期号：4
出版社：IJCSI Press
摘要：The aim of this work is to apply optimal control theory to certain cancer treatment strategies which based on combination of multiple cancer therapies, in the form of a system of ordinary differential equations (ODEs), governing cancer growth on cell population level with more than one of therapy, in order to determine the best mix of treatments that minimizes both tumor mass and negative effects upon the health of the patient. Numerical simulations of mixed chemotherapy and immunotherapy shows that neither chemotherapy nor immunotherapy alone are effective in treating the cancer, but in combination the therapies are able to eliminate the entire tumor.
关键词：chemotherapy; immunotherapy; optimal control theory; Pontryagin's Maximum principle.
