期刊名称：International Journal of Differential Equations
印刷版ISSN：1687-9643
电子版ISSN：1687-9651
出版年度：2018
卷号：2018
DOI：10.1155/2018/6710575
出版社：Hindawi Publishing Corporation
摘要：The aim of this paper is to study the early stage of HBV infection and impact delay in the infection process on the adaptive immune response, which includes cytotoxic T-lymphocytes and antibodies. In this stage, the growth of the healthy hepatocyte cells is logistic while the growth of the infected ones is linear. To investigate the role of the treatment at this stage, we also consider two types of treatment: interferon- (IFN) and nucleoside analogues (NAs). To find the best strategy to use this treatment, an optimal control approach is developed to find the possibility of having a functional cure to HBV.
