期刊名称：Annals of Agricultural and Environmental Medicine
印刷版ISSN：1232-1966
电子版ISSN：1898-2263
出版年度：2018
卷号：25
期号：1
页码：60-65
DOI：10.5604/12321966.1233573
出版社：Institute of Agricultural Medicine in Lublin
摘要：Introduction. Growth hormone deficiency (GHD) is one of the main indications for growth hormone therapy. Onecharacteristic of this disease is bone age delay in relation to the chronological age. Pituitary dysfunction negatively affectsthe growth and development of the jaws and teeth of the child. The secretion of endocrine glands regulates growth,development, and gender differentiation. It also controls the growth of bones and teeth, regulates metabolism of calciumand phosphate, proteins, lipids and carbohydrates. The primary role in the endocrine system is played by the pituitarygland which is responsible for the production of somatotropin[1]. Dysfunction of the pituitary gland has a negative effecton the growth and development of long bones in the body, and may have an adverse effect on the development of maxilla,mandible and dentition of a child. There is some information in the literature that dental age is delayed in short staturechildren; the replacement of deciduous teeth by permanent teeth is also delayed, and newly erupted permanent teethoften require orthodontic treatment. Applying hormonal therapy positively affects the process of replacement of dentition[2, 3, 4, 5, 6].Objectives. The aim of the study was to assess bone and dental age, as well as analyze the state of dentition in childrendiagnosed with GH deficiency treated with growth hormone, depending on the duration of treatment.Materials and method. The study material consisted of 110 children (27 males, 83 females), hospitalized for somatotropinhypopituitarism in the Department of Paediatric Endocrinology and Diabetology at the Medical University of Lublin, Poland.The mean birth age was 13 years (156 months) with a standard deviation of 2 years and 6 months (30 months).47 children (43%) started treatment with the growth hormone (group starting treatment) and 63 children (57%) whosetreatment was started 2–3 years previously (group in the course of treatment). The control group consisted of 41 generallyhealthy children (15males, 25 females) with ENT problems, such as hypoacusis and a condition after nasal injury, hospitalizedin the Department of Paediatric Otolaryngology at the Medical University of Lublin, Poland. The mean age was 11 yearsand 5 months (137 months) with standard deviation of 2 years and 5 months (29 months). Informed consent was obtainedfrom the parents.The study was approved by the Bioethical Committee at the Medical University of Lublin (Resolution No. KE-0254 /216 /2012).
关键词：somatotropic pituitary hypofunction; malocclusion; dental age
