期刊名称：Annals of Agricultural and Environmental Medicine
印刷版ISSN：1232-1966
电子版ISSN：1898-2263
出版年度：2017
卷号：24
期号：4
页码：587-591
DOI：10.5604/12321966.1232092
出版社：Institute of Agricultural Medicine in Lublin
摘要：Introduction and objective. A decreased concentration of iron, and consecutively haemoglobin, ferritin and decreasedlevel of saturated transferrin, were observed in obese individuals more often than in healthy subjects. The purpose of thisstudy was to determine whether iron, ferritin, transferrin saturation are significantly diminished in obese female patientscompared to non-obese counterparts, and whether excess adiposity and inflammation were associated with depleted iron.Materials and methods. Female patients (n=48) diagnosed with obesity (BMI > 30 kg/m2), aged 18–40 were acceptedfor the study. A control group (n=30) encompassed normal weight women, aged 18–30. All obese women obtained anindividually adjusted dietary plan with an energy content of 1,500 kcal. Blood glucose, insulin, lipids, ferritin, TIBC and ironconcentrations were assayed in serum twice, initially and after 8 weeks of dieting.Results. The obese women at the initial evaluation, in comparison to non-obese control women, were characterized by asignificantly lower mean red blood cell volume (MCV; 84.2±12.4 vs. 91.3±9.3 fL; p<0,0001), serum iron level (92.6±42.4 vs.119.8±44.0 μg/dL; p<0.01), and transferrin saturation (TSAT; 25.9±12.7 vs. 38.8±15.7%; p<0.01), but by higher plasma level ofthe C-reactive protein (CRP; 7.0±6.7 vs. 1.2±1.3 mg/L; p<0.01). The obese women after 8 weeks of diet decreased their meantotal body weight from 104.1±21.3 to 99.2±20.7 kg (p<0,0001). CRP level decreased slightly but significantly from 6.9±7.1 to6.2±7.5 (p<0.05).Conclusions. Obese women exhibit an increased level of CRP which may affect iron homeostasis. Weight loss leads todecrease in the CRP level, but it does not change haematologic parameters in the period of 8 weeks.
