期刊名称：Annals of Agricultural and Environmental Medicine
印刷版ISSN：1232-1966
电子版ISSN：1898-2263
出版年度：2017
卷号：24
期号：4
页码：610-617
DOI：10.5604/12321966.1232555
出版社：Institute of Agricultural Medicine in Lublin
摘要：Background. The work is designed to uncover the pattern of mutual relation among trace elements and epidemiologicaldata in the degenerated intervertebral disk tissue in humans. Hitherto the reason of the degenerative process is not fullyunderstood. Trace elements are the basic components of the biological compound related both its metabolism as well asenvironmental exposure. The relation pattern among elements occurs gives new perspective in solving the cause of thedisease.Methods. We have analysed trace elements content in the 30 intervertebral disc from 22 patients with degenerative discdisease. The concentrations of Al, Cu, Cd, Mo, Ni and Pb were determined with Atomic Absorption Spectrometry. To analysethe multidimentional relation between trace element concentration and epidemiological data the chemometric analysiswas applied.Results. The similarity have been shown in occurrence of following pairs: Cd-Mo as well as Mg-Zn. The second pair wascorrelated with Pb concentration. Pb levels are observed to be competitive to Cu concentration. Cd concentration wasrelated to Zn and Mg deficiency. No single but rather cluster of epidemiological data show observable influence on the TEtissue variance. Zn and Cu was related to the male sex. Operation with orthopedic implants were related to combined Al,Mo and Zn concentration.Conclusions. This is the first chemometric analysis of trace elements in disk tissue. It shows multidimentional relations thatare missed by the classical statistic. The analysis shows significant relation. The nature of the relations is the basis for furthermetabolic and environmental research.
