期刊名称：Annals of Agricultural and Environmental Medicine
印刷版ISSN：1232-1966
电子版ISSN：1898-2263
出版年度：2017
卷号：24
期号：3
页码：435-439
DOI：10.26444/aaem/75891
出版社：Institute of Agricultural Medicine in Lublin
摘要：Introduction and objective. The γ-amino butyric acid (GABA) plays important role in the proliferation and migration ofcancer cells. The aim of the study was to evaluate the level of GABA in breast cancer, in relation to clinical and epidemiologicaldata.Materials and method. The study was conducted on 89 patients with breast cancer in stage I-II. GABA level was assessedusing spectrofluorometric method in tumour homogenates. Immunoexpression of E-cadherin was evaluated histologicallyon paraffin fixed specimens. Overall and disease-free survival was assessed for a 15-year interval period.Results. Median overall survival was significantly longer (127.2 months) in patients with a high level of GABA (>89.3 μg/1),compared with a group with a low level of the amino acid (106.4 months). Disease-free survival was insignificantly different– 99 and 109 months, respectively. A significantly longer overall survival (131.2 months) was seen among patients with ahigh level of GABA and positive E-cadherin immunoexpression, compared with a group characterized by a low level of GABAand lack of E-cadherin immunorectivity (98.1 months). The co-existence of negative immunoexpression of E-cadherin andlow GABA concentration resulted in a six-fold increase in the risk of death (HR=6.03).Conclusion. GABA has a significant prognostic value in breast cancer. Co-existence of a low level of GABA and loss ofE-cadherin immune-expression seems to be a new, independent, and negative prognostic marker of the neoplasm.
