标题：Relationships between serum selenium and zinc concentrations versus profibrotic and proangiogenic cytokines (FGF-19 and endoglin) in patients with alcoholic liver cirrhosis
期刊名称：Annals of Agricultural and Environmental Medicine
印刷版ISSN：1232-1966
电子版ISSN：1898-2263
出版年度：2017
卷号：24
期号：3
页码：544-548
DOI：10.26444/aaem/76937
出版社：Institute of Agricultural Medicine in Lublin
摘要：Introduction and objective. Liver cirrhosis is a disease involving the liver parenchyma, which is characterised by fibrosis.and impaired architectonics of the parenchyma with regenerative nodules. The aim of the study was to determine therelationship between stage of alcoholic liver cirrhosis, concentrations of selenium, zinc and profibrotic and proangiogeniccytokines (FGF-19, ENG).Materials and method. The study included 99 patients with alcoholic cirrhosis and 20 healthy subjects. Ion chromatographywith UV/VIS detection was used for determination of zinc ions in the previously mineralized serum samples. The measurementsof selenium were performed with the ContrAA700 high-resolution continuum source graphite tube atomic absorptionspectrometer. ELISA was used to determine concentration of FGF-19 and ENG in serum samples.Results. Concentrations of zinc and selenium were significantly decreased in cirrhotic patients (p<0.001 for both). The highestconcentration of FGF-19 was found in Child-Pugh stage C liver cirrhosis patients (806.9±650.3 pg/ml), and was significantlyhigher than observed in controls (p=0.005) and stage A patients (compensated cirrhosis) (p=0.02). The highest concentrationof ENG was demonstrated in the control group (3.24±148 ng/ml) while the lowest in patients with decompensated cirrhosis(7.32±5.39 ng/ml and 7.92±4.18 ng/ml for stage B and C; p=0.03 and p=0.02, respectively). The use of the multiple-variablemodel demonstrated that the independent factors affecting the concentration of ENG were the concentration of bilirubin(p=0.02), INR (p=0.01) and duration of alcohol abuse (p=0.02). The independent determinants of FGF-19 concentrationswere found to be the stage (severity) of liver cirrhosis (p=0.04) and INR (p=0.03).Conclusions. Concentrations of zinc and selenium in serum of patients with alcoholic liver cirrhosis are not independentlyrelated to concentrations of FGF-19 and ENG.
