期刊名称：Annals of Agricultural and Environmental Medicine
印刷版ISSN：1232-1966
电子版ISSN：1898-2263
出版年度：2017
卷号：24
期号：2
页码：288-293
DOI：10.5604/12321966.1235176
出版社：Institute of Agricultural Medicine in Lublin
摘要：Introduction and objective. Low levels of serum vitamin D have been associated with increased occurrence of ischemicheart disease (IHD), but findings are inconsistent, e.g. seasonal variation is not always considered in the analyses. The aimof this study was to investigate whether vitamin D is associated with IHD among rural middle-aged men in Sweden whenseasonal variation is taken into account.Materials and method. A nested case-control study was performed within a population-based cohort of Swedish farmersand rural residents followed for 20 years. Outcomes were from national health registers. For 276 cases (IHD at any timeduring follow-up), and for 276 aged-matched controls free of cardiovascular diseases or diabetes, serum levels of vitaminD (25-hydroxyvitamin D3) were analyzed with liquid chromatography/tandem mass spectrometry (LC/MS/MS), in storedblood samples drawn at the baseline survey in 1990–91. The odds ratio (OR) with 95% confidence intervals (CI) of IHD forvitamin D-quartiles (based on measured as well as adjusted for month of sampling) was evaluated in logistic regressionmodels; potential confounders were taken into account.Results. The measured mean vitamin D levels were 27.6 ng/ml(standard deviation (sd)8.2 ng/ml) and 28.8 ng/ml (sd 9.0)among cases and controls, respectively. Compared to the quartile with the lowest month-adjusted vitamin D levels, therisk of IHD was significantly lower in the highest quartile (OR=0.46, 95% CI 0.25–0.84, p=0.012) in the fully-adjusted model.Conclusion. Rural Swedish men in the highest quartile of serum vitamin D had halved relative risk of IHD, compared tothose in the lowest quartile.
