标题:Comparative study on usefulness of gentamycin-containing collagen implants in the treatment of patients with osteitis and osteomyelitis of the craniofacial skeleton
期刊名称:Annals of Agricultural and Environmental Medicine
印刷版ISSN:1232-1966
电子版ISSN:1898-2263
出版年度:2017
卷号:24
期号:2
页码:299-302
DOI:10.5604/12321966.1235182
出版社:Institute of Agricultural Medicine in Lublin
摘要:Introduction and objective. A reduction in incidences of peri-surgical complications due to infections is achieved byantibiotic prophylaxis The objective of the study was to assess the usefulness of gentamycin-containing collagen implants(GCCI) in the treatment of patients with osteitis and osteomyelitis of the craniofacial skeleton.Materials and method. The retrospective study included 103 patients with osteitis and osteomyelitis. 54 patients weretreated intra-operatively with GCCI (Garamycin, EusaPharma, Europe). 49 patients were treated according to standardprocedures. Light microscopy and in vitro culture techniques were applied for bacteria specific identification, and toinvestigate the resistance of detected microbiota to antibiotics. Patients received one dose of antibiotic pre-operatively.Post-operative antibiotic treatment was administered individually, according to clinical course and microbiological tests.The patients were followed-up on days 3, 7 and 14 after discharge for local complications; radiographic follow-up wasperformed 3, 6 and 12 months after surgery.Results. The course of post-operative antibiotic therapy was shorter in GCCI patients than in the control group (median 1vs. 7 days); they also required shorter hospitalization (median 3 vs. 4 days). Implantation of GCCI significantly reduced theincidence of local complications (OR 0.30, 95%CI 0.11–0.83, p<0.0001), independently of the use of postoperative antibiotictherapy. On follow-up after 3–12 months, all patients presented with good soft tissue and bone healing.Conclusions. The results of this comparative study advocate the use of GCCI in osteomyelitis of various origin in oral andmaxillofacial surgery, as they seemed to reduce the incidence of local complications, shorten antibiotic administrationtime and hospital stay.