摘要:This study was conducted to study the effect of yeast culture ( Saccharomyces cerevisiae ) supplementation either alone or in combination with Propionibacterium freudenreichii strain P169 on nutrient digestibility coefficients, blood metabolites , milk yield and milk composition of mild lactating buffaloes. Fifteen lactating buffaloes, 2 months after parturition, were randomly assigned into three groups, 5 animals each, using complete random design. The experiment lasted for two months, buffaloes were fed dry matter according to 3% of their mean body weight. The experimental groups were fed on: (1) Control ration (consisted of 50% concentrate feed mixture (CFM), 30% corn silage, 10% dried sugar beet pulp and 10% rice straw), (2) Control ration+50 g Yeast Culture (YC)/head/day and (3) Control ration+50 g YC+4 g propionibacteria, P169, (YC+P169)/head/day. The supplementation of YC or YC+P169 improved (p<0.05) all nutrients digestibility but significantly decreased (p<0.05) blood plasma urea nitrogen of treated buffaloes. Milk and 4% fat corrected milk yields were significantly increased (p<0.05) while milk fatty acid s were unaffected by YC or YC+P169 supplementation. In conclusion, rations supplementation with YC or YC+P169 had beneficial effects on the buffaloes productivity with no deleterious effects on animals health.