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  • 标题:Development of Probiotic Formulation for the Treatment of Iron Deficiency Anemia
  • 本地全文:下载
  • 作者:Davor Jovan Korčok ; Nada Aleksandar Tršić-Milanović ; Nevena Djuro Ivanović
  • 期刊名称:Chemical and Pharmaceutical Bulletin
  • 印刷版ISSN:0009-2363
  • 电子版ISSN:1347-5223
  • 出版年度:2018
  • 卷号:66
  • 期号:4
  • 页码:347-352
  • DOI:10.1248/cpb.c17-00634
  • 语种:English
  • 出版社:The Pharmaceutical Society of Japan
  • 摘要:Probiotics are increasingly more present both as functional foods, and in pharmaceutical preparations with multiple levels of action that contribute to human health. Probiotics realize their positive effects with a proper dose, and by maintaining a declared number of probiotics cells by the expiration date. Important precondition for developing a probiotic product is the right choice of clinically proven probiotic strain, the choice of other active components, as well as, the optimization of the quantity of active component of probiotic per product dose. This scientific paper describes the optimization of the number of probiotics cells in the formulation of dietary supplement that contains probiotic culture Lactobacillus plantarum 299v, iron and vitamin C. Variations of the quantity of active component were analyzed in development batches of the encapsulated probiotic product categorized as dietary supplement with the following ingredients: probiotic culture, sucrosomal form of iron and vitamin C. Optimal quantity of active component L. plantarum of 50 mg, was selected. The purpose of this scientific paper is to select the optimal formulation of probiotic culture in a dietary supplement that contains iron and vitamin C, and to also determine its expiration date by the analysis of the number of viable probiotic cells.
  • 关键词:Lactobacillus plantarum 299v;iron;development;anemia;stability
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