摘要：Two new prenylated flavones, artocarnin A ( 2 ) and carpachromenol ( 12 ), together with 13 known prenylflavonoids ( 1 , 3 – 11 , 13–15 ) were isolated from the twigs of Artocarpus nigrifolius for the first time. Their structures were elucidated by high resolution-electrospray ionization (HR-ESI)-MS, NMR spectroscopic analysis, and in comparison with the reported data. Compounds 1 – 15 were evaluated for their antiproliferative effects against SiHa and SGC-7901 human cancer cell lines in vitro . The most active compound, eleocharin A ( 10 ), showed significant cytotoxicity on SiHa cells (IC50=0.7±0.1 µM) and inhibitory activity against SGC-7901 cells (IC50=8.3±0.2 µM) and could be considered as potential lead compound for further development of novel anti-tumor agents.
