摘要:The article aims to demonstrate a high efficiency of the methodological means suggestedby psychological syndrome analysis approach (Vygotsky-Luria school) for solving theoreticaland applied issues in contemporary person-centered medicine.This is achieved through an example of empirical study meant to construct a psychosomaticsyndrome for 290 patients with mitral valve prolapse (MVP). Analysis of allcollected data was based on psychological syndrome analysis concept (Vygotsky–Luriaschool) and A.R. Luria’s principles for psychological factors (causes) selection, whichdetermine the logic and structure of a neuropsychological syndrome. It demonstratedthe association between characteristics of emotional experiences and clinical symptomsmanifested in MVP patients. This correlation was statistically verified. The results provedthat the most important syndrome-establishment factor (radical) is a specific emotionalityand dysfunction of emotion regulation and emotional control in MVP patients(excessive emotional repression with insufficient reflection of emotional experiences).Features of the motivation sphere of MVP patients appear as a second psychologicalsyndrome-establishment factor: these are domination of the motive of failure avoidanceand unsatisfied self-approval need.We argue that psychological syndrome analysis can be used as a means to approach notonly diagnostic but also prognostic tasks both in clinical psychology and medicine, aswell as for the development and implementation of the person-centered integrative diagnosismodel.We maintained that this approach, applied in theoretical and practical fields of clinicalpsychology and mental health care is highly efficient at the current stage of the scienceevolution due to prospects revealed by s new methodological context of postnonclassicalmodel of rationality and a comprehensive character of the cultural-historical conceptregarding an individual and his mind as a self-developing open systems.