期刊名称：Studia Universitatis Moldaviae: Stiinte Sociale
印刷版ISSN：1814-3199
电子版ISSN：2345-1017
出版年度：2017
卷号：6
期号：106
页码：96-107
出版社：Moldova State University
摘要：This paper presents a review of N(4)-arilthiosemicarbazide derivatives. The synthesis methods of N(4)-arylthiosemicarbazidesand their derivatives are described. There are also represented the possible ways of modification of theirbiological properties. The antiproliferative activity towards HeLa, MCD-7, SW620, MiaPaCa-2, and Hep-2 cancer cellsand antimicrobial activity of these substances are revealed. These biological properties make it possible to use them asthe basis for the obtaining of new performant molecular inhibitors that can be used in anticancer therapy. Some ways ofthe development of organic synthesis for the obtaining of new derivatives of N(4)-arilthiosemicarbazides were outlined.
关键词：N(4)-arilthiosemicarbazide; N(4)-arilthiosemicarbazone; methods of the synthesis; biological activity.
