文章基本信息

标题：SINTEZA ȘI STUDIUL UNOR N’-(n-DIMETILFENIL)-N,N-DIMETILTIOUREI ȘI N(4)-n-DIMETILFENIL-TIOSEMICARBAZIDE
作者：Tatiana ERHAN ; Olga GARBUZ ; Aurelian GULEA 等
期刊名称：Studia Universitatis Moldaviae: Stiinte Sociale
印刷版ISSN：1814-3199
电子版ISSN：2345-1017
出版年度：2017
卷号：1
期号：101
页码：89-95
出版社：Moldova State University
摘要：The present paper describes the synthesis of 6 new thiosemicarbazides and 6 thioureas. The identity and purity ofobtained organic compounds was proved by chromatography TSS, melting points, as well as by 13C and 1H NMR, IRspectra. The synthesized substances were tested, in vitro for the antiproliferative activity on cancer and normal cells of:HeLa (cervical cancer) cells, BxPc-3 (pancreatic cancer) cells, RD (rhabdomyosarcoma) cells and on normal MDCKcells. Structure-activity relationships were carried out.
关键词：N (4)-n-dimethylphenyl-3-thiosemicarbazide; N'-(n-dimethylphenyl)-N;N-dimethylthiourea; antiproliferative;activity; HeLa; BxPc-3; RD; MDCK.