摘要:The purposes of this research were to investigate the influence from 5 personality types toward the Work-Family Conflict (WFC) on the nurses. During October to November in 2014, 100 questionnaires were distributed to the respondents to collect data in the A. Makkasau General Hospital Parepare by utilized nonprobability sampling method that is purposive sampling. Statistical tool that utilized in this research was SPSS version 20 for Windows software. The multiple regression analysis result shows that Conscientiousness was significant and negatively influencing for t-value around -2.142 with significance level for 0.035. Neuroticism is positively contributing to WFC with t-value around 2.656 and significance level for 0.010. Extraversion was negatively influencing and did not bring significant impact on WFC with t-value around -.0 730 and significance level for 0.468. Agreeableness was negatively influencing and did not significantly contributing to the WFC with t-value around 1.897 and significance level on 0.062. Openness to Experience was negatively influencing with t-value around - .0767 with significance level on 0.445.The findings suggest that 1) Conscientiousness was significantly and negatively influencing the WFC, which means supported by hypothesis 1; 2) Neuroticism also significantly and positively contributing to the WFC, which means supported the Hypothesis 2; 3) Organization should be able to realize that the economic costs from WFC are high and should be able to deal with the problems byimplementing work flexibility for example.Personality role and benefit from work and family would not reduce an individual responsibility on organization. Thus, it can help employees to balance their working and personal life. Personality types also can help whether to increase or even to decrease the WFS. An employee’ understanding can minimize the WFC itself also will maximize the program of the organization effectively. As an example, a training program will help a neurotic type employee to understandstheir on how to perceive a negative experience.