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  • 标题:Beneficial Effects of Different Flavonoids on Vascular and Renal Function in L-NAME Hypertensive Rats
  • 本地全文:下载
  • 作者:M. Dolores Paredes ; Paola Romecín ; Noemí M. Atucha
  • 期刊名称:Nutrients
  • 电子版ISSN:2072-6643
  • 出版年度:2018
  • 卷号:10
  • 期号:4
  • 页码:484
  • DOI:10.3390/nu10040484
  • 语种:English
  • 出版社:MDPI Publishing
  • 摘要:Background: we have evaluated the antihypertensive effect of several flavonoid extracts in a rat model of arterial hypertension caused by chronic administration (6 weeks) of the nitric oxide synthesis inhibitor, L-NAME. Methods: Sprague Dawley rats received L-NAME alone or L-NAME plus flavonoid-rich vegetal extracts (Lemon, Grapefruit + Bitter Orange, and Cocoa) or purified flavonoids (Apigenin and Diosmin) for 6 weeks. Results: L-NAME treatment resulted in a marked elevation of blood pressure, and treatment with Apigenin, Lemon Extract, and Grapefruit + Bitter Orange extracts significantly reduced the elevated blood pressure of these animals. Apigenin and some of these flavonoids also ameliorated nitric oxide-dependent and -independent aortic vasodilation and elevated nitrite urinary excretion. End-organ abnormalities such as cardiac infarcts, hyaline arteriopathy and fibrinoid necrosis in coronary arteries and aorta were improved by these treatments, reducing the end-organ vascular damage. Conclusions: the flavonoids included in this study, specially apigenin, may be used as functional food ingredients with potential therapeutic benefit in arterial hypertension.
  • 关键词:flavonoids; nitric oxide; heart; kidney; sodium balance; phenylephrine; acetylcholine flavonoids ; nitric oxide ; heart ; kidney ; sodium balance ; phenylephrine ; acetylcholine
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