As mining and environmental regulations continue to get tighter on mine closure and reclamation, the choice of an optimal post mining land use becomes critical if mining companies are to continue enjoying the peaceful co-existence they have with their local communities. In this study, possible mine closure alternatives have been identified as suitable for the Salman south pit of Adamus Resources Limited in the Western Region of Ghana. These alternatives are: arable farm land; timber production; shrubs and native forestation; aquaculture; water reservoir; land fill; and recreational site (park). Effective consideration has been given to the identified technical, environmental, economic, and social criteria to assist in the determination of the optimal choice among the identified suitable closure alternatives. Using the Preference Ranking Organisation Method for Enrichment Evaluation (PROMETHEE) technique of multi-criteria decision analysis, it was observed from the results that arable farmland was the most preferred choice followed very closely by timber production. Others like aquaculture, recreational site (park), shrubs and native forestation, water reservoir, and landfill followed in a decreasing order. In order to satisfy all the various stakeholders in the mine closure process, it is therefore recommended that arable farmland and/or timber production be adopted as the optimal post mining land use for the study area.