Market knowledge management is a relatively new construct in the current literature of business and management sciences. It is considered by some researchers and scholars as a possible miracle cure not only to obtain more and better results in small enterprises but also to improve significantly their level of business return. Similarly, the adoption and implementation of market knowledge management allow small enterprises to achieve more and better competitive advantages, a better market ranking and a significant increase in their business return. Therefore, this empirical research aims to analyze the prevailing relation between market knowledge management and the level of business return in small enterprises. In order to do this, a sample of 364 small and medium-sized enterprises was used from Aguascalientes State (Mexico). The results obtained show that market knowledge management has a positive and significant influence in the business return of small enterprises.