In the last presidential election of the United States (2016), the interaction between the Donald Trump and the American media was remarkable and unprecedented from both political and communication perspectives. The present paper is interested in observing the interactions between then the Republican Party candidate, Donald Trump, and the media of the United States. As there were major verbal confrontations between Trump, and some media, specifically CNN, this paper observes how Trump campaign reacted to CNN that turned out to be one of his biggest opponents. The relations and reactions are explained using “agenda setting” and “selective exposure” as theories and “thematic analysis” as the research methodology. The paper analyzes CNN videos from October 7 to October 31, and Trump’s tweets during the same period. The reason for conducting the research during October is that this month is regarded as one of the most critical periods in US presidential election, known as “October surprise”. Then a thematic analysis of the data is conducted to extract all accusations and allegations against Trump. Research results show that President Trump did not react to most of the accusations and attacks raised by CNN. Apparently Trump had decided that ignoring and not responding is a better strategy. There was an exception to this rule: Trump’s treatment toward women. He did address that issue frequently and tried to justify himself and apologize. Accordingly, Trump’s presidential campaign aim was to ignore accusations, keep attacking, and answering accusations only if they are already known to too many people.