In order to ensure the crude oil pipeline process smoothly, the driving force has a certain exergy loss. Based on the exergy analysis method, according to the required minimum potential difference of pipeline transportation, the unavoidable exergy loss is defined in the process. In order to reflect the real effective utilization degree of energy consumption, the unavoidable exergy loss rate is put forward as the evaluation index. And it is calculated by the ratio of related the unavoidable exergy loss and the exergy loss. The crude oil pipeline exergy loss rate is calculated under different conditions. The orthogonal experiment analysis used to compare the influence degree of different operating parameters on the pipeline unavoidable exergy loss rate show that the influence degree on the unavoidable exergy loss rate in turn is: outbound temperature, flow and outbound pressure. It also provide the reference for the energy-saving transportation of crude oil pipeline.