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  • 标题:Alloimmunization in Thalassemia Patients: New Insight for Healthcare
  • 本地全文:下载
  • 作者:Ali Davoudi-Kiakalayeh ; Reza Mohammadi ; Ali Akbar Pourfathollah
  • 期刊名称:INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE
  • 印刷版ISSN:2008-7802
  • 出版年度:2017
  • 卷号:8
  • 页码:101
  • DOI:10.4103/ijpvm.IJPVM_246_16
  • 语种:English
  • 出版社:ISFAHAN UNIVERSITY OF MEDICAL SCIENCES
  • 摘要:Background: Development of alloantibodies against the foreign red blood cell (RBC) (alloimmunization) is a well-known complication in thalassemia patients when performing multiple transfusions. The study was conducted to know the prevalence of alloimmunization in thalassemia patients, in the Caspian Sea coastline. Methods: This study is a descriptive, retrospective analysis of transfusion records of 190 patients with β-thalassemia major who received regular transfusions. To detect the type of alloantibodies, two cells panel tests (kits; Iranian Blood Transfusion Organization [IBTO], 3 RBC cells and IBTO, 11 RBC cells) were used. Results: Forty-seven patients were positive for alloantibodies (24.7%). Of them, 18.4% (35 cases) had only one alloantibody, and 6.3% (12 cases) had at least two or more of alloantibodies. The vast majority of alloantibodies were anti-Kell followed by anti-E, and anti-D, respectively. Conclusions: Blood matching for Rh and K antigens in patients with transfusion-dependent thalassemia could reduce the rate of RBC alloinununization.
  • 关键词:Alloantibody ; blood transfusion ; Iran ; thalassemia
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