标题：Psychosocial Determinants of Health-Related Quality of Life of People Living with HIV/AIDS on Antiretroviral Therapy at Udupi District, Southern India
摘要：Background: Life expectancy of people living with HIV/AIDS (PLHA) on antiretroviral therapy has appreciably increased. However, psychosocial challenges pose a great threat to their health-related quality of life (HRQOL). The aim of this study was to determine psychosocial factors influencing health-related quality of life of PLHA on antiretroviral therapy. Methods: A cross-sectional study was conducted using convenience sampling to select 226 PLHA at District hospital. Demographic information was collected using a semistructured questionnaire. HRQOL was assessed using WHOQOL-HIV Bref. The Hospital Anxiety and Depression Scale, CAGE scale, and Multidimensional Scale of Perceived Social Support were used. One-way ANOVA was applied. Results: There was a significant difference in mean quality of life score with respect to level of anxiety in the physical ( P < 0.001), psychological ( P < 0.001), level of independence ( P < 0.001), social relationships ( P = 0.047), environment ( P < 0.001), and spirituality domain ( P < 0.001). Significant difference in mean quality of life score was observed with respect to level of depression in physical ( P = 0.003), psychological ( P = 0.036), level of independence ( P = 0.017), social relationships ( P = 0.019), and spirituality ( P = 0.001). Friend support was positively associated with HRQOL in physical ( P < 0.001), psychological ( P < 0.001), level of independence ( P = 0.013), social relationships ( P < 0.001), environment (0.001), and spirituality domain (0.026). Family support was positively associated with HRQOL in physical ( P = 0.001), psychological ( P = 0.001), level of independence ( P = 0.040), social relationships ( P = 0.008), environment (0.001), and spirituality domain (0.026). A significant difference was observed with respect to affiliation to social organization in social relationships domain ( P = 0.044). Conclusions: Psychosocial challenges including anxiety, depression, and social support impact upon all domains of HRQOL of PLHA.
关键词：Antiretroviral therapy; health-related quality of life; one way ANOVA; people living with HIV/AIDS; psychosocial
