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  • 标题:Changing the Treatment of Permanent Neonatal Diabetes Mellitus from Insulin to Glibenclamide in a 4-Month-Old Infant with KCNJ11 Activating Mutation
  • 本地全文:下载
  • 作者:Homa Ilkhanipoor ; Zohreh Karamizadeh
  • 期刊名称:INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE
  • 印刷版ISSN:2008-7802
  • 出版年度:2013
  • 卷号:4
  • 期号:9
  • 页码:1078-1081
  • 语种:English
  • 出版社:ISFAHAN UNIVERSITY OF MEDICAL SCIENCES
  • 摘要:Permanent neonatal diabetes mellitus (PNDM) is a rare type of diabetes and KCNJ11 gene activating mutation is one of its prevalent causes. We introduced a 4-month-old male infant with poor feeding, restlessness, tachypnea, hyperglycemia, metabolic acidosis, and ketonemia. He was discharged with insulin and after 2 months, KCNJ11 gene mutation was found and treatment was switched from subcutaneous insulin to oral glibenclamide. Now, he is 1 year old with desirable glycemic control; therefore, genetic study is recommended for KCNJ11 gene mutation in such patients because if the mutation is found, treatment can be switched from insulin to sulfonylurea.
  • 关键词:KCNJ11; permanent neonatal diabetes mellitus; sulfonylurea
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