出版社：THE SCHOOL OF PUBLIC HEALTH, TEHRAN UNIVERSITY OF MEDICAL SCIENCES
摘要：Background: Animal studies have shown antioxidant effects of Royal Jelly (RJ) and its effect on insulin resistance as the most common complication of Type 2 diabetes. This study was conducted to determine the effect of RJ intake on serum total antioxidant capacity, Malondialdehyde and insulin resistance in T2DM. Methods: In this randomized controlled trial, forty-six type 2 diabetic patients, aged 25–65 years, with BMI of 20–30 kg/m2, and HbA1c of 6–8% were included. The patients were randomly assigned to receive 1000 mg of RJ supplement or placebo, 3 times daily for 8 weeks. HOMA-IR, anthropometric measurements, fasting blood glucose, serum insulin, total antioxidant capacity and malondialdehyde level were measured. Results: In comparison with placebo, HOMA-IR decreased ( P =0.015) while serum total antioxidant capacity increased significantly in RJ group ( P =0.016). No significant difference was detected for serum insulin and MDA in two groups. Conclusions: RJ intake may have favorable effects on serum TAC and HOMA-IR in diabetic patients.
关键词：Royal Jelly; Type 2 diabetes mellitus; Insulin resistance; Total antioxidant capacity
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