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  • 标题:A Randomized, Controlled Trial of Levonorgestrel Vs. The Yuzpe Regimen as Emergency Contraception Method among Iranian Women
  • 作者:Fatemeh Sadat Hoseini ; Mohammad Eslami ; Mohammed Abbasi
  • 期刊名称:Iranian Journal of Public Health
  • 印刷版ISSN:2251-6085
  • 电子版ISSN:2251-6093
  • 出版年度:2013
  • 卷号:42
  • 期号:10
  • 页码:1158-1166
  • 语种:English
  • 出版社:THE SCHOOL OF PUBLIC HEALTH, TEHRAN UNIVERSITY OF MEDICAL SCIENCES
  • 摘要:Background We aimed to compare acceptability of Levonorgestrel with the Yuzpe regimen among Iranian women based on their side-effects and resulting changes in the amount and pattern of menses. Methods Five hundred twenty nine participants aged 15-49 having regular menses and one act of unprotected intercourse within 72 h were included in the double-blind, controlled trial in 2006-2007 and randomly assigned into LNG (n=263) and HD (n=266) groups, receiving Levonorgestrel 0.75 mg given 12 h apart and ethinyl estradiol 100 μg plus 0.5 mg Levonorgestrel 0.5 mg repeated after 12 h, respectively. Results The participants receiving Levonorgestrel experienced significantly lower side-effects in the case of nausea, vomiting, and dizziness ( P <0.05). The changes occurred in the amount and pattern of menses were the same for both groups ( P >0.05). No significant difference was observed between the efficiencies of the treatments. Conclusion Significantly lower side-effects of Levonorgestrel can be considered as greater acceptability and translated to higher efficiency.
  • 关键词:Levonorgestrel; Yuzpe regimen; Emergency contraception; Side-effects
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