摘要：Terreinlactone A ( 1a/1b ), a pair of 3-substituted δ-lactone enantiomers, and terreinlactone B ( 2 ), a new biosynthetic intermediate of 1a/1b , were isolated from Aspergillus terreus , along with their biosynthetic precursor (+)-terrein ( 3 ) and (+)-isoterrein ( 4 ). Compounds 1a and 1b were separated by using a Daicel chiral-pak ASH column eluting with n -hexane–EtOH (80 : 20). The structures of 1a/1b with absolute configurations were determined by comprehensive spectroscopic analyses and electronic circular dichroic (ECD) calculations. Terreinlactone A ( 1 ) represents the first example of 1,5- seco -terrein and a biogenetic pathway is proposed from the precursor terrein via the intermediated terreinlactone B ( 2 ).
