其他摘要：Background : Diabetes mellitus is a metabolic disorder with multiple etiologies. Its sufferers are generally at high risk of dyslipidemia characterized by hypercholesterolemia, hyper-triglyceridemia, hyperlipoproteinemia and low levels of high-density lipoprotein cholesterol. Globally, the estimated cost of diabetes care was $376 billion in 2010, representing 12% of health expenditures for that year. Methods : The effects of the aqueous extracts of a little known Nigerian traditional polyherbal formula consisting of Emilia coccinea , Acanthus montanus , Hibiscus rosasinensis and Asystasia gangetica on serum glucose concentration, amylase activity and lipid profiles of normal, diabetic, and liver-damaged rabbits were studied using standard procedures. The mixture of the aqueous extracts of the four plants was orally administered in two doses – 120mg/kg body weight and 240mg/kg body weight for 28 days. Results : The drug elicited dose- and duration-of-administration-dependent, significant (p<0.05) reductions in serum levels of glucose, total cholesterol, triacylglycerol and LDL-cholesterol; and significant (p<0.05) increases in the HDL-cholesterol concentrations with no changes in amylase activity. Conclusion : These results confirm the hypoglycemic, antihyperlipidemic and hepatoprotective potentials of the crude drug and thus justify its application in ethnomedicine in the management of diabetes. Key words : Emilia coccinea , Acanthus montanus , Hibiscus rosasinensis , Asystasia gangetica , antidiabetic, hepatoprotection.
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